The pharmacological assay as a tool to medicinal plants domestication

Autor/innen

  • Ilio Montanari Jr. Chemical, Biological and Agricultural Pluridisciplinary Research Center at Campinas State University (CPQBA-UNICAMP), Av. Alexandre Cazelatto 999, 13.148-000 Paulínia-SP, Brazil
  • Ana Lúcia Tasca Gois Ruiz Chemical, Biological and Agricultural Pluridisciplinary Research Center at Campinas State University (CPQBA-UNICAMP), Av. Alexandre Cazelatto 999, 13.148-000 Paulínia-SP, Brazil
  • Carlos Amilcar Parada Chemical, Biological and Agricultural Pluridisciplinary Research Center at Campinas State University (CPQBA-UNICAMP), Av. Alexandre Cazelatto 999, 13.148-000 Paulínia-SP, Brazil
  • João Ernesto de Carvalho Chemical, Biological and Agricultural Pluridisciplinary Research Center at Campinas State University (CPQBA-UNICAMP), Av. Alexandre Cazelatto 999, 13.148-000 Paulínia-SP, Brazil

DOI:

https://doi.org/10.5073/jka.2016.453.019

Schlagworte:

medicinal plants, pharmacological effects, domestication

Abstract

In Brazil studies with native medicinal plants are usually performed using non-domesticated plants and as a result the genetic variability of wild species could express different levels of active principles changing their therapeutic effect. Based on that, the aim of this study was to demonstrate that extract of different half- sib families Cordia verbenacea (DC), widely used as medicinal plant in Brazil, have different efficacy in the Total Growth Inhibition (TGI) of 5 different human tumor cell lines. Data were statistically analyzed using ANOVA follow by Tuckey test and a heritability estimation of the plant families was performed. The results showed that TGI are different for each plant family according with each human tumor cell line. For instance, extracts obtained from families 3,11 and 12 were more effective to inhibit the U-251 and Ht-29 cell lines compared to the other families, while extracts obtained from the family 32 was more effective against thethe PC-3 line. The heritability coefficient indicated that plant population selection could promote a genetic improvement related to its active principle and their pharmacological effect and could provide the identification of the best families according to their pharmacological efficacy. In conclusion, this study suggests that the domestication of a wild medicinal plant should be better monitored by its pharmacological effect.

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Veröffentlicht

2016-07-26

Ausgabe

Rubrik

Session E: Ex situ and in situ genetic recourses – protection and use by colleting practice – cultivation of new species