VitisPathways: gene pathway analysis for V. vinifera
Keywords:Vitis vinifera, pathway, Fishers exact test, gene expression, genomics, proteomics
Pathway enrichment analysis of genetic and proteomic data is fraught with multiple testing and other interpretive issues. A web-based tool, VitisPathways, was developed to simplify the process of pathway analyses for Vitis researchers while maintaining statistical robustness. Because enrichment analysis tools outside of pathway analysis have shown non-regularity to multiple test corrections, simulations were used to assess the degree of regularity in Vitis knowledgebases and its impact on interpretation. This tool is freely available and can be an aide to hypothesis generation in transcriptomic studies of Vitis.
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