Exogenous application of RNA for the eco-friendly control of insect pests

Abstract

Under the perspective of high social demands for sustainable and environmentally friendly crop protection, RNA sprays represent an innovative and promising alternative to conventional synthetic pesticides. Due to sequence specificity, custom-made RNAs not only provide high selectivity but can also be easily adapted to target different species. Consequently, they can be available more quickly compared to the time-consuming development of conventional synthetic pesticides. Despite the multiple benefits and the desperate need for alternatives, field application of RNA sprays is still in its infancy. Here, we discuss the challenges resulting from scientific-technical, social and economic demands. In addition, we identify open research questions that need to be addressed to establish RNAi-based products in a timely manner. Moreover, we highlight recent examples of innovative solutions, which could inspire further optimization of RNA sprays for the control of insect pests in the field. Parts of this article have already been presented in a broader review article (Rank & Koch 2021) and are embedded here into a more detailed context. The presentation in German should also make them accessible to a broader readership.